Severe Drug-Induced Agranulocytosis Successfully Treated with Recombinant Human Granulocyte Colony-Stimulating Factor
نویسندگان
چکیده
When elderly patients are prescribed many different medications, the risk for developing serious adverse events should be kept in mind. One of these adverse events is agranulocytosis, which, although rare, can be life-threatening if left untreated. The majority of agranulocytosis cases are caused by drugs, including antibiotics. Here, we report a case of severe agranulocytosis in a 96-year-old woman following antibiotic therapy which was successfully managed using recombinant human granulocyte colony-stimulating factor (rhG-CSF) and the appropriate choice of antibiotics to treat her concomitant infection.
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Council for International Organizations and Medical Sciences time relationship criteria are important to use (2). First, if the time window is too narrow, a delay between onset of agranulocytosis and diagnosis might obscure the causative drug. Second, some drugs associated with agranulocytosis have long half-lives and thus may be present in the body even more than 1 month after drug withdrawal....
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عنوان ژورنال:
دوره 2018 شماره
صفحات -
تاریخ انتشار 2018